The Red Sox appeared headed to an impressive 4-3 come-from-behind victory when J.D. Drew delivered a go-ahead homer for Boston in the top of the eighth. But the bullpen betrayed that advantage in Baltimore, as Orioles third baseman Miguel Tejada smashed a game-tying homer off of Daniel Bard in the eighth inning, then delivered a game-winning single back up the middle in the bottom of the 10th against Manny Delcarmen, as Baltimore claimed a 5-4, walkoff victory. (Recap.)

WHAT WENT RIGHT FOR THE RED SOX

–John Lackey was spectacular at times for the Sox. He featured a terrific curveball and slider that helped him to a season-high six strikeouts. He allowed three runs (two earned) in seven innings, allowing just five hits (four singles and a double), while throwing a whopping 120 pitches.

Lackey became the first Sox pitcher to throw 120 pitches this year. Entering Friday, all major league hurlers had combined to throw just nine games of 120 or more pitches.

–J.D. Drew entered Friday with just one multi-hit game in 2010, two homers and a .181/.282/.306/.588 line. But the right-fielder smashed a pair of solo homers — one to left-center on a fastball from David Hernandez in the second inning, and another to dead center on a Jim Johnson fastball in the eighth inning — for his fifth multi-homer game as a Red Sox, and his first of the 2010 season.

–Dustin Pedroia continued his current hot streak, going 2-for-4 with a homer to right-center and 2 RBI. He is now 10-for-26 (.385) in his last six games. His homer was his first since April 17, and just the third opposite field homer of his career. His six homers in April matched his career-high for any month (previously achieved in August 2008).

WHAT WENT WRONG FOR THE RED SOX

–The Red Sox defense, anticipated to be a strong suit this year, continued its disappointing path. A pair of errors led to a key unearned run in the fourth, as center fielder Darnell McDonald kicked a leadoff single to center by Miguel Tejada, then, after a walk put runners on first and second, third baseman Adrian Beltre booted a double-play grounder to allow a run.

Beltre was also caught out of the position in the first inning, when he was heading towards the bag on a planned pickoff throw to third. Matt Wieters shot a run-scoring single to left through the vacated hole.

Beltre in particular has made several sloppy plays this season (five errors), but the Sox defense as a whole has also been well short of advertised. Entering Friday, the Sox had a .691 defensive efficiency, ranked 19th among the 30 major league teams.

–Daniel Bard grooved a 96 mph fastball to Miguel Tejada in the bottom of the eighth that the third baseman slammed deep into the left-field stands for a game-tying solo homer. It was the third homer that Bard has allowed in 14.2 innings this year. He gave up five longballs in 49.1 innings in the 2009 season.

–Beltre’s challenging evening did not stop there. He was also thrown out at third on a strike-’em-out, throw-’em-out double play, and was called for baserunner interference in the top of the seventh, thus turning what would have been a force out at second into a double play. The interference call (which was debatable) may have cost the Sox a run, since with two outs, McDonald walked and both Marco Scutaro and Pedroia singled, a rally that yielded one run but could have resulted in more.

Beltre did, however, go 3-for-5 to improve his average to .338.