Jon Lester

After handing Angels No. 1 pitcher Jered Weaver his first loss of the season Monday night, the Red Sox now get to face the Angels’ 1-A starter in Dan Haren on Tuesday night. Haren, who is 4-1 this season, ranks second in the American League in ERA (1.23) and first in WHIP (0.75). As is the case with Weaver, Haren’s only loss came against the Sox. He gave up four runs (two earned) on five hits and three walks over six innings in a 4-3 Boston win on April 22.

With the loss, Haren dropped to 2-6 against the Sox in his career, although he does have a solid 3.19 ERA and 1.19 WHIP against them. David Ortiz has had plenty of success against Haren — he’s hitting .318 with three home runs and six RBIs in 22 career at-bats — but most of the Sox have struggled with him. As a team, Boston is hitting just .216 off Haren. No one has had a tougher go of it than Dustin Pedroia, who is 0-for-12 with a walk and five strikeouts in 13 plate appearances.

The Sox will counter Haren with an ace of their own in Jon Lester, who is 3-1 with a 2.52 ERA and 1.12 WHIP this season. The 27-year-old southpaw also opposed Haren in that April 22 game, and he earned the win by tossing six shutout innings. Lester, who has won each of his last three starts, improved to 3-1 against the Angels in his career. But in a reverse of Haren’s situation, Lester has a less-than-stellar 4.81 ERA and 1.63 WHIP against them.

Current Angels are hitting .238 against Lester. Torii Hunter has had the most success, as he is hitting .375 with a homer and four RBIs in 16 ABs. Vernon Wells, Bobby Abreu and Howie Kendrick — the three players with the most ABs — are all hitting .200 or worse against Lester.

Lester vs. Angels

Vernon Wells (38 career plate appearances): .194 BA/.316 OBP/.355 SLG, 1 HR, 3 RBI, 5 walks, 3 strikeouts

Bobby Abreu (24): .200/.333/.300, 3 RBI, 4 walks, 4 strikeouts

Howie Kendrick (20): .158/.200/.211, 1 walk, 4 strikeouts

Erick Aybar (19): .313/.421/.375, 2 RBI, 3 walks

Torii Hunter (18): .375/.444/.688, 1 HR, 4 RBI, 2 walks, 3 strikeouts

Alberto Callaspo (9): .143/.333/.286, 2 walks, 2 strikeouts

Maicer Izturis (9): .375/.444/.625, 2 RBI, 1 walk

Jeff Mathis (9): .250/.250/.375, 3 strikeouts

Peter Bourjos (3): .333/.333/.667, 2 strikeouts

Mark Trumbo (2): .000/.000/.000, 1 strikeout

Hank Conger and Bobby Wilson have never faced Lester.

Haren vs. Red Sox

Adrian Gonzalez (45): .268/.295/.463, 2 HR, 6 RBI, 2 walks, 10 strikeouts

Carl Crawford (30): .241/.267/.379, 4 RBI, 1 walk, 6 strikeouts

David Ortiz (25): .318/.400/.818, 3 HR, 6 RBI, 3 walks, 1 strikeout

Kevin Youkilis (16): .188/.188/.188, 1 RBI, 4 strikeouts

J.D. Drew (15): .200/.200/.267, 1 RBI, 6 strikeouts

Dustin Pedroia (13): .000/.077/.000, 1 walk, 5 strikeouts

Jason Varitek (11): .100/.182/.200, 5 strikeouts

Marco Scutaro (10): .125/.200/.250, 2 RBI, 1 walk, 1 strikeout

Mike Cameron (9): .000/.111/.000, 1 walk, 5 strikeouts

Jacoby Ellsbury (6): .250/.500/.500, 1 RBI, 2 walks, 1 strikeout

Jarrod Saltalamacchia (6): .333/.333/.667, 1 strikeout

Jed Lowrie (5): .500/.600/1.000, 1 walk, 2 strikeouts

Darnell McDonald (3): .000/.500/.000